( 7)ĪCE inhibitors, Angiotensin Receptor Blockers (ARB), or Beta-Blockers: Concomitant use with naproxen sodium may diminish the antihypertensive effect of these drugs. Concomitant use of naproxen sodium and analgesic doses of aspirin is not generally recommended. warfarin, aspirin, SSRIs/SNRIs): Monitor patients for bleeding who are concomitantly taking naproxen sodium with drugs that interfere with hemostasis. ( 5.12, 7)ĭrugs that Interfere with Hemostasis (e.g. Hematologic Toxicity: Monitor hemoglobin or hematocrit in patients with any signs or symptoms of anemia. Avoid use of NSAIDs in women at about 30 weeks gestation and later in pregnancy due to the risks of oligohydramnios/fetal renal dysfunction and premature closure of the fetal ductus arteriosus. (5.9)ĭrug Reaction with Eosinophilia and Systemic Symptoms (DRESS): Discontinue and evaluate clinically ( 5.10).įetal Toxicity: Limit use of NSAIDs, including naproxen sodium, between about 20 to 30 weeks in pregnancy due to the risk of oligohydramnios/fetal dysfunction. Serious Skin Reactions: Discontinue naproxen sodium at first appearance of skin rash or other signs of hypersensitivity. Monitor patients with preexisting asthma (without aspirin sensitivity). ( 5.7)Įxacerbation of Asthma Related to Aspirin Sensitivity: Naproxen sodium is contraindicated in patients with aspirin-sensitive asthma. ( 5.6)Īnaphylactic Reactions: Seek emergency help if an anaphylactic reaction occurs. Avoid use of naproxen sodium in patients with advanced renal disease unless benefits are expected to outweigh risk of worsening renal function. Renal Toxicity: Monitor renal function in patients with renal or hepatic impairment, heart failure, dehydration, or hypovolemia. Heart Failure and Edema: Avoid use of naproxen sodium in patients with severe heart failure unless benefits are expected to outweigh risk of worsening heart failure. Hypertension: Patients taking some antihypertensive medications may have impaired response to these therapies when taking NSAIDs. Discontinue if abnormal liver tests persist or worsen or if clinical signs and symptoms of liver disease develop. Hepatotoxicity: Inform patients of warning signs and symptoms of hepatotoxicity. Naproxen sodium tablets may also be used at a starting dose of 825 mg followed by 275 mg every 8 hours. Naproxen sodium is recommended for the management of acute painful conditions when prompt onset of pain relief is desired. The initial total daily dose should not exceed 1,375 mg of naproxen sodium.Thereafter, the total daily dose should not exceed 1,100 mg of naproxen sodium. Recommended starting dose 550 mg of naproxen sodium as naproxen sodium tablets is followed by 550 mg every 12 hours or 275 mg every 6 to 8 hours as required. Management of Pain, Primary Dysmenorrhea, and Acute Tendonitis and Bursitis In patients who tolerate lower doses well, the dose may be increased to naproxen 1,500 mg/day for up to 6 months. The dose may be adjusted up or down depending on the clinical response of the patient. Rheumatoid Arthritis, Osteoarthritis, and Ankylosing Spondylitis Naproxen Sodium Tablets Use the lowest effective dosage for shortest duration consistent with individual patient treatment goals.
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